Involvement of protein kinase C-epsilon in glucocorticoid-induced apoptosis in thymocytes.

@article{Iwata1994InvolvementOP,
  title={Involvement of protein kinase C-epsilon in glucocorticoid-induced apoptosis in thymocytes.},
  author={M. Iwata and R Iseki and Kenzo Sato and Yuzuru Tozawa and Yoshiharu Ohoka},
  journal={International immunology},
  year={1994},
  volume={6 3},
  pages={431-8}
}
Apoptosis is induced in immature thymocytes by physiological peak levels of glucocorticoid hormones, especially in murine and rat cells. Endogenous glucocorticoids may have some role in thymic selection. Glucocorticoid-induced thymocyte apoptosis appears to be dependent on protein kinase C (PKC), since it is inhibited by PKC inhibitors. PKC is a family of closely related enzymes, consisting of Ca(2+)-dependent (PKC-alpha, -beta I, -beta II, and -gamma) and Ca(2+)-independent (PKC-delta… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

Rescuing developing thymocytes from death by neglect.

Journal of biochemistry and molecular biology • 2002
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…