Involvement of protein kinase A and A kinase anchoring protein in the progesterone-initiated human sperm acrosome reaction.

@article{Harrison2000InvolvementOP,
  title={Involvement of protein kinase A and A kinase anchoring protein in the progesterone-initiated human sperm acrosome reaction.},
  author={David A. Harrison and Daniel J J Carr and Stanley Meizel},
  journal={Biology of reproduction},
  year={2000},
  volume={62 3},
  pages={811-20}
}
The signal transduction pathways involved in the progesterone (P(4))-initiated mammalian sperm acrosome reaction (AR) are not fully understood. To investigate the role of the protein kinase A (PKA) pathway in the P(4)-initiated AR, we probed this pathway by pretreating capacitated human sperm with reagents designed to either inhibit PKA activation or disrupt PKA/A kinase anchoring protein (AKAP) interactions. Preincubation with the stearated (membrane permeable) PKA inhibitor, PKI alpha 5-24 (S… CONTINUE READING

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