Involvement of proteasomes in regulating Jak-STAT pathways upon interleukin-2 stimulation.

Abstract

Interleukin-2 (IL-2) activates the receptor-associated Janus family tyrosine kinases, Jak1 and Jak3, which in turn phosphorylate and activate specific STAT proteins (signal transducers and activators of transcription), such as STAT5. Activation of Jak and STAT proteins by IL-2 is transient and the mechanism for the subsequent down-regulation of their… (More)

Topics

Cite this paper

@article{Yu1997InvolvementOP, title={Involvement of proteasomes in regulating Jak-STAT pathways upon interleukin-2 stimulation.}, author={C. L. Yu and Steven J. Burakoff}, journal={The Journal of biological chemistry}, year={1997}, volume={272 22}, pages={14017-20} }