Involvement of prostaglandin E2 in production of amyloid-beta peptides both in vitro and in vivo.

@article{Hoshino2007InvolvementOP,
  title={Involvement of prostaglandin E2 in production of amyloid-beta peptides both in vitro and in vivo.},
  author={Tatsuya Hoshino and Tadashi Nakaya and Takashi Homan and Ken-ichiro Tanaka and Yukihiko Sugimoto and Wataru Araki and Masami Narita and Shuh Narumiya and Toshiharu Suzuki and Tohru Mizushima},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 45},
  pages={32676-88}
}
Amyloid-beta peptides (Abeta), generated by proteolysis of the beta-amyloid precursor protein (APP) by beta- and gamma-secretases, play an important role in the pathogenesis of Alzheimer disease (AD). Inflammation is also believed to be integral to the pathogenesis of AD. Here we show that prostaglandin E(2) (PGE(2)), a strong inducer of inflammation, stimulates the production of Abeta in cultured human embryonic kidney (HEK) 293 or human neuroblastoma (SH-SY5Y) cells, both of which express a… CONTINUE READING