Involvement of prostaglandin E receptor EP3 subtype in duodenal bicarbonate secretion in rats.

@article{Aihara2007InvolvementOP,
  title={Involvement of prostaglandin E receptor EP3 subtype in duodenal bicarbonate secretion in rats.},
  author={Eitaro Aihara and Yoko Nomura and Yoko Sasaki and Fumitaka Ise and Kazutomo Kita and Koji Takeuchi},
  journal={Life sciences},
  year={2007},
  volume={80 26},
  pages={2446-53}
}
We investigated the involvement of prostaglandin E (PGE) receptor subtype EP3 in the regulatory mechanism of duodenal HCO(3)(-) secretion in rats. A proximal duodenal loop or a chambered stomach was perfused with saline, and HCO(3)(-) secretion was measured using a pH-stat method and by adding 2 mM HCl. Mucosal acidification was achieved through 10 min of exposure to 10 mM HCl in the duodenum or 100 mM HCl in the stomach. Various EP agonists or the EP4 antagonist were given i.v., while the EP1… CONTINUE READING

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