Involvement of progesterone receptors in ascorbic acid-mediated protection against ischemia-reperfusion-induced acute kidney injury.

@article{Sandhi2014InvolvementOP,
  title={Involvement of progesterone receptors in ascorbic acid-mediated protection against ischemia-reperfusion-induced acute kidney injury.},
  author={Jasmine Sandhi and Jaswinder Pal Singh and Tajpreet Kaur and Sarvpreet Singh Ghuman and Amrit Pal Singh},
  journal={The Journal of surgical research},
  year={2014},
  volume={187 1},
  pages={
          278-88
        }
}
Protective Effect of PACAP on Ischemia/Reperfusion-Induced Kidney Injury of Male and Female Rats: Gender Differences
TLDR
Pituitary adenylate cyclase-activating polypeptide is protective in ischemia/reperfusion-induced kidney injury in both sexes, but females had markedly less pronounced injury after ischemIA/rePerfusion, the investigation of which could have future therapeutic value in treating ischemic kidney injuries.
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Dipyridamole attenuates ischemia reperfusion induced acute kidney injury through adenosinergic A1 and A2A receptor agonism in rats
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It is concluded that adenosine receptors find their definite involvement in DYP-mediated anti-oxidative and reno-protective effect against ischemia reperfusion-induced acute kidney injury (AKI) in rats.
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TLDR
Using progesterone as an adjuvant agent against ovarian damage in patients undergoing cancer chemotherapy with cisplatin is beneficial, and decreases in TUNEL-positive cells are shown.
Progesterone ameliorates diabetic nephropathy in streptozotocin-induced diabetic Rats
TLDR
Evidence is provided, for the first time, that the replacement of progesterone can ameliorate the renal damage in the experimental models of diabetic nephropathy through improving the renal function; the inhibition of renal fibrosis and abnormal angiogenesis; along with theAmelioration of podocyte injury.
Investigation the protective effect of vitamin C on anxiety and oxidative stress modulation in male rats treated with progesterone
TLDR
Progesterone (5 mg/kg) has anxiogenic effect and at the high doses, progesterone has anxiolytic effect and as an antioxidant, vitamin C can improve the anxIOlytic effects of progester one.
Mitochondrial Dysfunction in Cardiorenal Syndrome 3: Renocardiac Effect of Vitamin C
TLDR
Data indicate that vitamin C provides protection to the kidneys and some beneficial effects to the heart after IR, indicating it may be a preventive approach against cardiorenal insults.
Hormonal Regulation of Renal Fibrosis
TLDR
This review considered renal fibrosis from the point of view of vasoactive and reproductive hormone imbalance, and the hormonal therapy possibilities for the treatment or prevention of kidney fibrosis are discussed.
Sex Differences in Renal Function: Participation of Gonadal Hormones and Prolactin
TLDR
The influence of sexual dimorphism and gonadal hormones on kidney damage is described, emphasizing the role of the hormone prolactin and its cleavage products, the vasoinhibins.
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References

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TLDR
The findings imply that reactive oxygen species play a causal role in I/R-induced renal injury, and that AA exerts renoprotective effects, probably by radical scavenging and antioxidant activities.
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Progesterone offers protection of the retina against IR injury in SD rats by increasing SOD activity and decreasing MDA content in the retina.
Ascorbic acid prevents ischemia-reperfusion injury in the rat small intestine
TLDR
It is indicated that AsA acts as an antioxidant against peroxidative tissue injury, possibly by scavenging radicals, preserving reduced GSH, and reducing the peroxIDative reaction.
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TLDR
The results suggest that pre-administration of a combination of NAC, SNP, and P attenuates renal ischemia/reperfusion injury, which has potential application in preservation of donor kidney for transplantation by protecting cells against free radical damage.
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TLDR
After ischemia, renal function recovery and tissue injury is gender-dependent and differences are associated with a modulation of sex hormone production and a modification of tissue remodeling and proliferative cell processes.
Protective effects of ascorbic acid pretreatment in a rat model of intestinal ischemia-reperfusion injury: a histomorphometric study.
TLDR
Ascorbic acid pretreatment has a protective effect against the intestinal morphological lesions induced by ischemia-reperfusion injury in rats.
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TLDR
Vitamin C administration proved to be effective in reducing the extent of myocardial damage during ISO-inducedMyocardial infarction in rats associated with an iNOS downregulation and improving the autonomic balancing of the heart.
Supplementation of ascorbic acid prevents oxidative damages in arsenic-loaded hepatic tissue of rat: An ex vivo study
TLDR
It is suggested that ascorbic acid is helpful to ameliorate arsenic-induced oxidative stress and may be one of the alternative screening systems to study the efficacy of antioxidant and hepatoprotective agent.
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