Involvement of pmrAB and phoPQ in polymyxin B adaptation and inducible resistance in non-cystic fibrosis clinical isolates of Pseudomonas aeruginosa.

@article{Schurek2009InvolvementOP,
  title={Involvement of pmrAB and phoPQ in polymyxin B adaptation and inducible resistance in non-cystic fibrosis clinical isolates of Pseudomonas aeruginosa.},
  author={Kristen N Schurek and Jorge Luiz de Mello Sampaio and Carlos Roberto Veiga Kiffer and Sumiko I. Sinto and Caio M{\'a}rcio Figueiredo Mendes and Robert E. Hancock},
  journal={Antimicrobial agents and chemotherapy},
  year={2009},
  volume={53 10},
  pages={4345-51}
}
During investigation of susceptibility testing methods for polymyxins, 24 multidrug-resistant clinical isolates of Pseudomonas aeruginosa were observed to have a distinct, reproducible phenotype in which skipped wells were observed during broth microdilution testing for polymyxin B. Possible mechanisms underlying this phenotype were investigated. The effects of various concentrations of polymyxin B on growth, the expression of resistance genes, and outer-membrane permeability were observed… CONTINUE READING

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