Involvement of phospholipase D1 in melanogenesis of mouse B16 melanoma cells.

@article{Ohguchi2004InvolvementOP,
  title={Involvement of phospholipase D1 in melanogenesis of mouse B16 melanoma cells.},
  author={Kenji Ohguchi and Y. Banno and Yukihiro Akao and Yoshinori Nozawa},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 5},
  pages={3408-12}
}
In response to alpha-melanocyte-stimulating hormone (alpha-MSH) or cAMP-elevating agents (forskolin and isobutylmethylxanthine), mouse B16 melanoma cells underwent differentiation characterized by increased melanin biosynthesis. However, the mechanism(s) underlying the regulation of melanogenesis during differentiation has not yet been clearly understood. Phospholipase D (PLD) has been reported to be involved in differentiation. This enzyme cleaves phosphatidylcholine upon stimulation with… CONTINUE READING

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