Involvement of phospholipase A2 activation in tumour cell killing by tumour necrosis factor.

@article{Neale1988InvolvementOP,
  title={Involvement of phospholipase A2 activation in tumour cell killing by tumour necrosis factor.},
  author={M. L. Neale and R A Fiera and N I Matthews},
  journal={Immunology},
  year={1988},
  volume={64 1},
  pages={81-5}
}
Earlier studies have indicated a possible role for arachidonate metabolism in the direct cytolysis of tumour cells by tumour necrosis factor (TNF) in vitro. In this study, the involvement of arachidonate metabolism has been investigated further with the following results: (i) Cytolysis of human U937 tumour cells by recombinant TNF was reduced by dexamethasone and quinacrine, agents which inhibit phospholipase A2. (ii) U937 and L929 cells, which are susceptible to TNF cytolysis, released… CONTINUE READING

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