Involvement of peroxiredoxin I in protecting cells from radiation-induced death.

  title={Involvement of peroxiredoxin I in protecting cells from radiation-induced death.},
  author={Bo Zhang and Yongping Su and Guoping Ai and Yanli Wang and Tao Wang and Fengchao Wang},
  journal={Journal of radiation research},
  volume={46 3},
Peroxiredoxin I (Prx-I), a key member of the peroxiredoxin family, reduces peroxides and equivalents through the thioredoxin system. Our previous work has shown that expression of Prx-I in mammalian cells increases following ionizing radiation (IR), indicating that Prx-I actively responds to IR-induced reactive oxygen species (ROS) and suggesting that Prx-I plays an important role in protecting cells from IR-induced death. To test this hypothesis, we suppressed the expression of Prx-I in SW480… CONTINUE READING
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