Involvement of p53 in DNA strand break-induced apoptosis in postmitotic CNS neurons.

@article{Enokido1996InvolvementOP,
  title={Involvement of p53 in DNA strand break-induced apoptosis in postmitotic CNS neurons.},
  author={Yasushi Enokido and Tsutomu Araki and Kohichi Tanaka and Shin Aizawa and Hiroshi Hatanaka},
  journal={The European journal of neuroscience},
  year={1996},
  volume={8 9},
  pages={1812-21}
}
The tumour suppressor p53 gene serves as a critical regulator of the cell cycle and of apoptosis following the exposure of normal cells to DNA damage. To examine the role of p53 in postmitotic CNS neurons, we cultured cerebellar neurons from normal wild-type mice and mutant p53-null mice under various conditions inducing neuronal death. When cerebellar neurons from 15- to 16-day postnatal wild-type mice were treated with ionizing radiation or DNA-damaging agents, massive neuron death occurred… CONTINUE READING