Involvement of p38MAPK and reactive oxygen species in icariin-induced cardiomyocyte differentiation of murine embryonic stem cells in vitro.

@article{Ding2008InvolvementOP,
  title={Involvement of p38MAPK and reactive oxygen species in icariin-induced cardiomyocyte differentiation of murine embryonic stem cells in vitro.},
  author={L. Ding and Xing-guang Liang and Y. Hu and Danyan Zhu and Y. Lou},
  journal={Stem cells and development},
  year={2008},
  volume={17 4},
  pages={
          751-60
        }
}
We previously reported that treatment of icariin could significantly induce cardiomyocyte differentiation of murine embryonic stem (ES) cells in vitro. In the present study, the exact activity initiated by icariin was further confirmed and the underlying molecular mechanism was investigated. We found that cardiomyocyte differentiation was efficiently stimulated only if icariin was administrated between days 5 and 8 in differentiation course, which indicated with elevated percentage of embryoid… Expand
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