Involvement of p38 mitogen-activated protein kinase followed by chemokine expression in crescentic glomerulonephritis.

@article{Wada2001InvolvementOP,
  title={Involvement of p38 mitogen-activated protein kinase followed by chemokine expression in crescentic glomerulonephritis.},
  author={Takashi Wada and Kengo Furuichi and Norihiko Sakai and Yukimasa Hisada and Karen M. Kobayashi and Naofumi Mukaida and Naohisa Tomosugi and Kouji Matsushima and Hitoshi Yokoyama},
  journal={American journal of kidney diseases : the official journal of the National Kidney Foundation},
  year={2001},
  volume={38 6},
  pages={1169-77}
}
p38 Mitogen-activated protein kinase (MAPK) is involved in the production and signal transduction of interleukin-1beta (IL-1beta), tumor necrosis factor-alpha, and chemokines in vitro. However, the crucial role of p38 MAPK in the inflammatory processes of crescentic glomerulonephritis in vivo remains to be investigated. We showed a dramatic decrease in IL-1beta-induced phosphorylation of p38 MAPK, not extracellular signal-regulated kinases 1/2 or jun NH2-terminal kinase, in rat cultured… CONTINUE READING
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