Involvement of p38 mitogen-activated protein kinase in gemcitabine-induced apoptosis in human pancreatic cancer cells.

@article{Habiro2004InvolvementOP,
  title={Involvement of p38 mitogen-activated protein kinase in gemcitabine-induced apoptosis in human pancreatic cancer cells.},
  author={Atsuya Habiro and Satoshi Tanno and Kazuya Koizumi and Tsutomu Izawa and Yasuhiro Nakano and Manabu Osanai and Yusuke Mizukami and Toshikatsu Okumura and Yutaka Kohgo},
  journal={Biochemical and biophysical research communications},
  year={2004},
  volume={316 1},
  pages={
          71-7
        }
}
In this study, we investigated the involvement of Akt and members of the mitogen-activated protein kinase (MAPK) superfamily, including ERK, JNK, and p38 MAPK, in gemcitabine-induced cytotoxicity in human pancreatic cancer cells. We found that gemcitabine induces apoptosis in PK-1 and PCI-43 human pancreatic cancer cell lines. Gemcitabine specifically activated p38 MAPK in a dose- and time-dependent manner. A selective p38 MAPK inhibitor, SB203580, significantly inhibited gemcitabine-induced… CONTINUE READING
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