Involvement of p21ras in Xenopus mesoderm induction

@article{Whitman1992InvolvementOP,
  title={Involvement of p21ras in Xenopus mesoderm induction},
  author={Malcolm R Whitman and Douglas A. Melton},
  journal={Nature},
  year={1992},
  volume={357},
  pages={252-254}
}
DURING early vertebrate embryogenesis, mesoderm is specified by a signal emanating from prospective endoderm. This signal can respecify Xenopus prospective ectoderm as mesoderm, and can be mimicked by members of the fibroblast growth factor and transforming growth factor-β families1,2. In other systems, the p21c-ras proto-oncogene product has been implicated in signal transduction for various polypeptide growth factors. We report here that a dominant inhibitory ras mutant blocks the mesoderm… CONTINUE READING
Highly Influential
This paper has highly influenced 11 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 54 extracted citations

Role of 14-3-3 proteins in early Xenopus development

Mechanisms of Development • 2002
View 6 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…