Involvement of p21ras in Xenopus mesoderm induction

  title={Involvement of p21ras in Xenopus mesoderm induction},
  author={Malcolm R Whitman and Douglas A. Melton},
DURING early vertebrate embryogenesis, mesoderm is specified by a signal emanating from prospective endoderm. This signal can respecify Xenopus prospective ectoderm as mesoderm, and can be mimicked by members of the fibroblast growth factor and transforming growth factor-β families1,2. In other systems, the p21c-ras proto-oncogene product has been implicated in signal transduction for various polypeptide growth factors. We report here that a dominant inhibitory ras mutant blocks the mesoderm… CONTINUE READING
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