Involvement of p21 and p27 in the regulation of CDK activity and cell cycle progression in the regenerating liver

@article{Albrecht1998InvolvementOP,
  title={Involvement of p21 and p27 in the regulation of CDK activity and cell cycle progression in the regenerating liver},
  author={Jeffrey H Albrecht and Randy YC Poon and Cory L. Ahonen and Brenda M Rieland and Chu-Xia Deng and Gretchen S. Crary},
  journal={Oncogene},
  year={1998},
  volume={16},
  pages={2141-2150}
}
In tissue culture systems, p21 and p27 inhibit cyclin-dependent kinase (CDK) activity and cell cycle progression in response to numerous stimuli, but little is known about their involvement in cell growth in vivo. We examined the modulation of CDK activity by these proteins after 70% partial hepatectomy (PH), an in vivo model of synchronous hepatocyte cell cycle progression. After PH in BALB/c mice, p21 was induced during the prereplicative (G1) phase and was maximally expressed after peak… CONTINUE READING
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