Involvement of oxidative stress in mutagenicity and apoptosis caused by dental resin monomers in cell cultures.

@article{Lee2006InvolvementOO,
  title={Involvement of oxidative stress in mutagenicity and apoptosis caused by dental resin monomers in cell cultures.},
  author={D. Lee and B. Lim and Y. Lee and S. Ahn and Hyeong-Cheol Yang},
  journal={Dental materials : official publication of the Academy of Dental Materials},
  year={2006},
  volume={22 12},
  pages={
          1086-92
        }
}
  • D. Lee, B. Lim, +2 authors Hyeong-Cheol Yang
  • Published 2006
  • Materials Science, Medicine
  • Dental materials : official publication of the Academy of Dental Materials
OBJECTIVE This investigation studied the possibility that apoptosis as well as mutagenicity induced by resin monomers are mediated by oxidative stress. METHODS A range of dilutions of three resin monomers (GMA, TEGDMA, and HEMA) was added to culture medium (DMEM/10% FBS), of V79-4 fibroblasts and RPC-C2A pulp cells for 24 h. Their cytotoxic effects were measured by a colorimetric functional assay (MTT). Chromosomal aberration induced by the resin monomers was investigated by counting… Expand
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References

SHOWING 1-10 OF 31 REFERENCES
Resin composite monomers alter MTT and LDH activity of human gingival fibroblasts in vitro.
  • 176
TEGDMA Causes Apoptosis in Primary Human Gingival Fibroblasts
  • 102
TEGDMA-induced toxicity in human fibroblasts is associated with early and drastic glutathione depletion with subsequent production of oxygen reactive species.
  • 196
  • Highly Influential
Effects of BisGMA on glutathione metabolism and apoptosis in human gingival fibroblasts in vitro.
  • 83
The Induction of Micronuclei in vitro by Unpolymerized Resin Monomers
  • 155
  • Highly Influential
Inhibition of Phosphatidylinositol 3-Kinase Amplifies TEGDMA-induced Apoptosis in Primary Human Pulp Cells
  • 96
  • Highly Influential
Effect of TEGDMA on the intracellular glutathione concentration of human gingival fibroblasts.
  • 84
Metabolic Effects of Dental Resin Components in vitro Detected by NMR Spectroscopy
  • 72
Genotoxicity and cytotoxicity of dental materials in human lymphocytes as assessed by the single cell microgel electrophoresis (comet) assay.
  • 118
Cytotoxic Effects of Resin Components on Cultured Mammalian Fibroblasts
  • 343
  • PDF
...
1
2
3
4
...