Involvement of organic anion transport system in transdermal absorption of flurbiprofen.

@article{Ito2007InvolvementOO,
  title={Involvement of organic anion transport system in transdermal absorption of flurbiprofen.},
  author={Katsuaki Ito and Yukio Kato and Hiroyuki Tsuji and Hai Thien Nguyen and Yoshiyuki Kubo and Akira Tsuji},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2007},
  volume={124 1-2},
  pages={
          60-8
        }
}
We previously demonstrated that transdermal permeation of flurbiprofen is mediated by a nonlinear transport mechanism(s). Here, we aimed to characterize this transport mechanism by employing an Ussing-type chamber method with tape-stripped hairless mouse skin. Transdermal permeation of [(3)H]flurbipofen was vectorial, saturable and energy-dependent, suggesting the involvement of a carrier-mediated transport system. Transdermal permeation and uptake from the epidermal side of [(3)H]flurbiprofen… CONTINUE READING

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Title P-Glycoprotein ( Abcb 1 ) is involved in absorptive drug transport in skin

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ATP binding cassette transporters in two distinct compartments of the skin contribute to transdermal absorption of a typical substrate.

Journal of controlled release : official journal of the Controlled Release Society • 2013
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Carnitine/organic cation transporter OCTN2 (Slc22a5) is responsible for renal secretion of cephaloridine in mice.

Drug metabolism and disposition: the biological fate of chemicals • 2009
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P-glycoprotein (Abcb1) is involved in absorptive drug transport in skin.

Journal of controlled release : official journal of the Controlled Release Society • 2008
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Method Support