Involvement of oligosaccharide changes in alpha5beta1 integrin in a cisplatin-resistant human squamous cell carcinoma cell line.

@article{Nakahara2003InvolvementOO,
  title={Involvement of oligosaccharide changes in alpha5beta1 integrin in a cisplatin-resistant human squamous cell carcinoma cell line.},
  author={Susumu Nakahara and Eiji Miyoshi and Katsuhisa Noda and Shinji Ihara and Jianguo G Gu and Koichi Honke and Hidenori Inohara and Takeshi Kubo and Naoyuki Taniguchi},
  journal={Molecular cancer therapeutics},
  year={2003},
  volume={2 11},
  pages={1207-14}
}
Multiple mechanisms are involved in the resistance of cancer cells to cisplatin, including the expression of multidrug resistance-associated protein (MRP) and enhanced DNA repair. Here, we report findings to show that oligosaccharide changes in alpha5beta1 integrin are associated with cisplatin resistance in a head and neck squamous cell carcinoma cell line, HSC-2. Cisplatin-resistant HSC-2 (HSC-2/CR) cells were established by stepwise treatment with various concentrations of cisplatin. The… CONTINUE READING

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