Involvement of oligomerization, N-glycosylation and sialylation in the clearance of cholinesterases from the circulation.

@article{Kronman1995InvolvementOO,
  title={Involvement of oligomerization, N-glycosylation and sialylation in the clearance of cholinesterases from the circulation.},
  author={Chanoch Kronman and Baruch Velan and Dino Marcus and Arie Ordentlich and Shaul Reuveny and Avigdor Shafferman},
  journal={The Biochemical journal},
  year={1995},
  volume={311 ( Pt 3)},
  pages={959-67}
}
The possible role of post-translational modifications such as subunit oligomerization, protein glycosylation and oligosaccharide processing on the circulatory life-time of proteins was studied using recombinant human acetylcholinesterase (rHuAChE). Different preparations of rHuAChE containing various amounts of tetramers, dimers and monomers are cleared at similar rates from the circulation, suggesting that oligomerization does not play an important role in determining the rate of clearance. An… CONTINUE READING