Involvement of nucleotide excision repair in a recombination-independent and error-prone pathway of DNA interstrand cross-link repair.

@article{Wang2001InvolvementON,
  title={Involvement of nucleotide excision repair in a recombination-independent and error-prone pathway of DNA interstrand cross-link repair.},
  author={Xuemei Wang and Carolyn A. Peterson and Huyong Zheng and Rodney S. Nairn and Randy J. Legerski and Lei Li},
  journal={Molecular and cellular biology},
  year={2001},
  volume={21 3},
  pages={713-20}
}
DNA interstrand cross-links (ICLs) block the strand separation necessary for essential DNA functions such as transcription and replication and, hence, represent an important class of DNA lesion. Since both strands of the double helix are affected in cross-linked DNA, it is likely that conservative recombination using undamaged homologous regions as a donor may be required to repair ICLs in an error-free manner. However, in Escherichia coli and yeast, recombination-independent mechanisms of ICL… CONTINUE READING