Involvement of nitric oxide-mediated intrinsic pathway signaling in age-related increase in germ cell apoptosis in male Brown-Norway rats.

@article{Hikim2005InvolvementON,
  title={Involvement of nitric oxide-mediated intrinsic pathway signaling in age-related increase in germ cell apoptosis in male Brown-Norway rats.},
  author={Amiya P. Sinha Hikim and Yanira Vera and Dolores A Vernet and Mark A Castanares and Maruja Diaz-Romero and M{\'o}nica Ferrini and Ronald S. Swerdloff and Nestor F. Gonzalez-Cadavid and Christina Wang},
  journal={The journals of gerontology. Series A, Biological sciences and medical sciences},
  year={2005},
  volume={60 6},
  pages={702-8}
}
We examined, using young and old Brown-Norway rats, the involvement of the nitric oxide (NO)-mediated intrinsic pathway signaling in age-related activation of male germ-cell apoptosis. Increased apoptosis of germ cells was readily observed in the normal-looking testes of old rats. Testicular NO synthase (NOS) activity, assessed by measuring the synthesis of (3)H-L-citrulline from (3)H-L-arginine, and cytokine-inducible NO synthase (iNOS) levels, assessed by western blot assay, were increased… CONTINUE READING

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Functional role of inducible nitric oxide synthase in the induction of male germ cell apoptosis, regulation of sperm number, and determination of testis size: evidence from null mutant mice

  • Y Lue, AP Sinha Hikim, C Wang, A Leung, RS. Swerdloff
  • Endocrinology
  • 2003
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