Involvement of nitric oxide in nitroprusside-induced hepatocyte cytotoxicity.

  title={Involvement of nitric oxide in nitroprusside-induced hepatocyte cytotoxicity.},
  author={Hossein Niknahad and Peter James O'Brien},
  journal={Biochemical pharmacology},
  volume={51 8},
Sodium nitroprusside (SNP) cytotoxicity towards rat hepatocytes was accompanied by peroxynitrite formation, lipid peroxidation, inhibition of glycolysis, cyanide (CN) release, partial inhibition of hepatocyte respiration, and ATP depletion. Antioxidants and desferoxamine prevented both cytotoxicity and lipid peroxidation induced by SNP. The CN antidote thiosulfate or the CN trapping agents dihydroxyacetone and glyceraldehyde increased SNP metabolism, SNP-induced peroxynitrite formation… CONTINUE READING