Involvement of nitric oxide in aminoglycoside vestibulotoxicity in guinea pigs.

@article{Nakagawa1999InvolvementON,
  title={Involvement of nitric oxide in aminoglycoside vestibulotoxicity in guinea pigs.},
  author={Tomoya Nakagawa and Hideo Yamane and Masahiro Takayama and Kishiko Sunami and Yuichiro Nakai},
  journal={Neuroscience letters},
  year={1999},
  volume={267 1},
  pages={57-60}
}
Involvement of nitric oxide (NO) has been reported in physiological and pathological conditions in the inner ear. Recently, the presence of nitric oxide synthase (NOS) was demonstrated in the vestibular epithelium. In this study we used nicotinamide adenine dinucleotide phosphate-diapholase staining to monitor NOS activity during degeneration of guinea pig vestibular epithelia affected by streptomycin. Increased NOS activity was observed in affected epithelia in a dose- and time-dependent… CONTINUE READING