Involvement of neutral sphingomyelinase in the angiotensin II signaling pathway.

@article{BautistaPrez2015InvolvementON,
  title={Involvement of neutral sphingomyelinase in the angiotensin II signaling pathway.},
  author={Roc{\'i}o Bautista-P{\'e}rez and Leonardo Del Valle-Mondrag{\'o}n and Agustina Cano-Mart{\'i}nez and {\'O}scar P{\'e}rez-M{\'e}ndez and Bruno A. Escalante and Martha Franco},
  journal={American journal of physiology. Renal physiology},
  year={2015},
  volume={308 10},
  pages={
          F1178-87
        }
}
The possibility that angiotensin II (ANG II) exerts its effects through the activation of neutral sphingomyelinase (nSMase) has not been tested in kidneys. The results of the present study provide evidence for the activity and expression of nSMase in rat kidneys. In isolated perfused rat kidney, ANG II-induced renal vasoconstriction was inhibited by GW4869, an inhibitor of nSMase. We used nSMase for investigating the signal transduction downstream of ceramide. nSMase constricted the renal… CONTINUE READING

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