Involvement of neuronal cell bodies of the mesencephalic locomotor region in the initiation of locomotor activity of freely behaving rats

@article{Brudzynski1986InvolvementON,
  title={Involvement of neuronal cell bodies of the mesencephalic locomotor region in the initiation of locomotor activity of freely behaving rats},
  author={Stefan M. Brudzynski and Pamela Elizabeth Houghton and Richard D. Brownlee and Gordon James Mogenson},
  journal={Brain Research Bulletin},
  year={1986},
  volume={16},
  pages={377-381}
}
The locomotor activity of freely-moving rats was increased substantially by injections of L-sodium glutamate or of picrotoxin, a GABA antagonist, into the region of the tegmental pedunculopontine nucleus. The onset of hyper-motility was more rapid with L-glutamate than with picrotoxin and the duration shorter. Locomotor activity from injecting amphetamine unilaterally into the nucleus accumbens was reduced by injections of GABA into the ipsilateral pedunculopontine nucleus. These observations… CONTINUE READING
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