Involvement of multiple kinases in neutrophil activation.

  title={Involvement of multiple kinases in neutrophil activation.},
  author={D J Lu and Wendy Furuya and Sergio Grinstein},
  journal={Blood cells},
  volume={19 2},
  pages={343-9; discussion 349-51}
Production of reactive oxygen metabolites by the NADPH oxidase is an essential mechanism underlying the microbicidal role of phagocytes. Receptor-mediated activation of the oxidase was originally thought to be mediated by calcium and/or by protein kinase C (PKC). However, recent evidence suggests that additional signalling pathways exist. In this article the possible role of tyrosine phosphorylation is discussed. In addition, results obtained using an in vitro kinase renaturation assay are… CONTINUE READING

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