Involvement of multiple intracellular release channels in calcium sparks of skeletal muscle.

@article{Gonzlez2000InvolvementOM,
  title={Involvement of multiple intracellular release channels in calcium sparks of skeletal muscle.},
  author={Adom Gonz{\'a}lez and Wolfgang G. Kirsch and Natalia Shirokova and Gonzalo Pizarro and Gustavo Brum and Isaac N Pessah and Michael D. Stern and Heping Cheng and Eduardo R{\'i}os},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2000},
  volume={97 8},
  pages={4380-5}
}
In many types of muscle, intracellular Ca(2+) release for contraction consists of brief Ca(2+) sparks. Whether these result from the opening of one or many channels in the sarcoplasmic reticulum is not known. Examining massive numbers of sparks from frog skeletal muscle and evaluating their Ca(2+) release current, we provide evidence that they are generated by multiple channels. A mode is demonstrated in the distribution of spark rise times in the presence of the channel activator caffeine… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.
48 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 48 extracted citations

Similar Papers

Loading similar papers…