Involvement of multidrug resistance-associated proteins in regulating cellular levels of (-)-epigallocatechin-3-gallate and its methyl metabolites.

@article{Hong2003InvolvementOM,
  title={Involvement of multidrug resistance-associated proteins in regulating cellular levels of (-)-epigallocatechin-3-gallate and its methyl metabolites.},
  author={Jungil Hong and Joshua D. Lambert and Sung Hack Lee and Patrick J. Sinko and Chung S. Yang},
  journal={Biochemical and biophysical research communications},
  year={2003},
  volume={310 1},
  pages={
          222-7
        }
}
Quercetin Increased the Antiproliferative Activity of Green Tea Polyphenol (-)-Epigallocatechin Gallate in Prostate Cancer Cells
TLDR
In summary, quercetin combined with EGCG in vitro demonstrated enhanced inhibition of cell proliferation by increasing the intracellular concentration of E GCG and decreasing EGCGs methylation.
Effect of genistein on the bioavailability and intestinal cancer chemopreventive activity of (-)-epigallocatechin-3-gallate.
TLDR
It is demonstrated that although genistein can enhance EGCG bioavailability and in vitro growth inhibitory activity, this combination enhances tumorigenesis in the APC(min/+) mouse, showing the need for careful cancer prevention studies in animal models and for caution when interpreting data from in vitro studies.
DOSE-DEPENDENT LEVELS OF EPIGALLOCATECHIN-3-GALLATE IN HUMAN COLON CANCER CELLS AND MOUSE PLASMA AND TISSUES
TLDR
The results suggest that absorption of EGCG from the small intestine is largely via passive diffusion; however, at high concentrations, the small intestinal and colonic tissues become saturated.
Quercetin increased bioavailability and decreased methylation of green tea polyphenols in vitro and in vivo.
TLDR
Combining quercetin with GT provides a promising approach to enhance the chemoprevention of GT and may vary by tissue depending on the intrinsic COMT and MRP activity.
Piperine enhances the bioavailability of the tea polyphenol (-)-epigallocatechin-3-gallate in mice.
TLDR
It is reported that cotreatment with a second dietary component, piperine (from black pepper), enhanced the bioavailability of EGCG in mice and demonstrated the modulation of the E GCG bioavailablity by a second Dietary component and illustrates a mechanism for interactions between dietary chemicals.
Modulation of function of three ABC drug transporters, P-glycoprotein (ABCB1), mitoxantrone resistance protein (ABCG2) and multidrug resistance protein 1 (ABCC1) by tetrahydrocurcumin, a major metabolite of curcumin
TLDR
This study clearly showed that THC inhibits the efflux function of P-gp, MXR and MRP1 and it is able to extend the MDR reversing activity of curcuminoids in vivo.
Green tea catechin, epigallocatechin-3-gallate, attenuates the cell viability of human non-small-cell lung cancer A549 cells via reducing Bcl-xL expression
TLDR
Results indicated that the inhibition of cell proliferation by EGCg may be achieved via suppressing the expression of the cell death-inhibiting gene, Bcl-xL.
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