Involvement of multidrug resistance-associated proteins in regulating cellular levels of (-)-epigallocatechin-3-gallate and its methyl metabolites.

@article{Hong2003InvolvementOM,
  title={Involvement of multidrug resistance-associated proteins in regulating cellular levels of (-)-epigallocatechin-3-gallate and its methyl metabolites.},
  author={Jungil Hong and Joshua D. Lambert and Sung Hack Lee and Patrick J. Sinko and Chung S. Yang},
  journal={Biochemical and biophysical research communications},
  year={2003},
  volume={310 1},
  pages={
          222-7
        }
}
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148 Citations
Highly Influential Citations
5
Background Citations
52
Methods Citations
5
Results Citations
3

148 Citations

Quercetin Increased the Antiproliferative Activity of Green Tea Polyphenol (-)-Epigallocatechin Gallate in Prostate Cancer Cells
TLDR
In summary, quercetin combined with EGCG in vitro demonstrated enhanced inhibition of cell proliferation by increasing the intracellular concentration of E GCG and decreasing EGCGs methylation.
N-Acetylcysteine enhances the lung cancer inhibitory effect of epigallocatechin-3-gallate and forms a new adduct.
Effect of genistein on the bioavailability and intestinal cancer chemopreventive activity of (-)-epigallocatechin-3-gallate.
TLDR
It is demonstrated that although genistein can enhance EGCG bioavailability and in vitro growth inhibitory activity, this combination enhances tumorigenesis in the APC(min/+) mouse, showing the need for careful cancer prevention studies in animal models and for caution when interpreting data from in vitro studies.
DOSE-DEPENDENT LEVELS OF EPIGALLOCATECHIN-3-GALLATE IN HUMAN COLON CANCER CELLS AND MOUSE PLASMA AND TISSUES
TLDR
The results suggest that absorption of EGCG from the small intestine is largely via passive diffusion; however, at high concentrations, the small intestinal and colonic tissues become saturated.
Epigallocatechin-3-gallate does not affect the activity of enzymes involved in metabolic activation and cellular excretion of benzo[a]pyrene in human colon carcinoma cells.
Quercetin increased bioavailability and decreased methylation of green tea polyphenols in vitro and in vivo.
TLDR
Combining quercetin with GT provides a promising approach to enhance the chemoprevention of GT and may vary by tissue depending on the intrinsic COMT and MRP activity.
Green tea polyphenol epigallocatechin-3-gallate shows therapeutic antioxidative effects in a murine model of colitis.
Piperine enhances the bioavailability of the tea polyphenol (-)-epigallocatechin-3-gallate in mice.
TLDR
It is reported that cotreatment with a second dietary component, piperine (from black pepper), enhanced the bioavailability of EGCG in mice and demonstrated the modulation of the E GCG bioavailablity by a second Dietary component and illustrates a mechanism for interactions between dietary chemicals.
Modulation of function of three ABC drug transporters, P-glycoprotein (ABCB1), mitoxantrone resistance protein (ABCG2) and multidrug resistance protein 1 (ABCC1) by tetrahydrocurcumin, a major metabolite of curcumin
TLDR
This study clearly showed that THC inhibits the efflux function of P-gp, MXR and MRP1 and it is able to extend the MDR reversing activity of curcuminoids in vivo.
Green tea catechin, epigallocatechin-3-gallate, attenuates the cell viability of human non-small-cell lung cancer A549 cells via reducing Bcl-xL expression
TLDR
Results indicated that the inhibition of cell proliferation by EGCg may be achieved via suppressing the expression of the cell death-inhibiting gene, Bcl-xL.
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References

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