Involvement of multidrug resistance-associated protein 2 (ABCC2/Mrp2) in biliary excretion of micafungin in rats.

@article{Abe2008InvolvementOM,
  title={Involvement of multidrug resistance-associated protein 2 (ABCC2/Mrp2) in biliary excretion of micafungin in rats.},
  author={Fumie Abe and Jun Ueyama and Akiko Kimata and Miki Kato and Tamon Hayashi and Masayuki Nadai and Hiroko Saito and Naoshi Takeyama and Hiroshi Noguchi and Takaaki Hasegawa},
  journal={Life sciences},
  year={2008},
  volume={83 7-8},
  pages={229-35}
}
The drug transporter, multidrug resistance-associated protein 2 (ABCC2/Mrp2), is known to play important roles in excretion of various drugs. In the present study, we investigated whether Mrp2 is involved in the transport of micafungin, a newly developed antifungal agent. When Sprague-Dawley rats received an intravenous injection of micafungin (1 mg/kg) in combination with cyclosporine, the cyclosporine significantly delayed the disappearance of micafungin from plasma and decreased the systemic… CONTINUE READING
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