Involvement of mucosal addressin cell adhesion molecule-1 (MAdCAM-1) in the pathogenesis of granulomatous colitis in rats.

@article{Hokari2001InvolvementOM,
  title={Involvement of mucosal addressin cell adhesion molecule-1 (MAdCAM-1) in the pathogenesis of granulomatous colitis in rats.},
  author={Ryota Hokari and Shingo Kato and Koji Matsuzaki and Atsuhiro Iwai and Atsushi Kawaguchi and Shigeaki Nagao and Toru Miyahara and Kazuro Itoh and Eiichi Sekizuka and Hiroshi Nagata and Hiromasa Ashitani Noriaki Ishii and Toshihiko Iizuka and Masayuki Miyasaka and Soichiro Miura},
  journal={Clinical and experimental immunology},
  year={2001},
  volume={126 2},
  pages={259-65}
}
Although increased expression of mucosal addressin cell adhesion molecule-1 (MAdCAM-1) has been demonstrated in inflammatory sites of various diseases, its role in colitis remains unknown. In this study, we examined whether MAdCAM-1 is involved in the pathogenesis of granulomatous colitis induced by peptidoglycan-polysaccharide (PG-PS). Experimental colitis was induced by intramural injection of PG-PS to rat colon. After 3 weeks the colon was removed and the mucosal inflammation was assessed… CONTINUE READING
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