Involvement of mu-opioid receptors in antinociception and inhibition of gastrointestinal transit induced by 7-hydroxymitragynine, isolated from Thai herbal medicine Mitragyna speciosa.

@article{Matsumoto2006InvolvementOM,
  title={Involvement of mu-opioid receptors in antinociception and inhibition of gastrointestinal transit induced by 7-hydroxymitragynine, isolated from Thai herbal medicine Mitragyna speciosa.},
  author={Kenjiro Matsumoto and Yoshio Hatori and Toshihiko Murayama and Kimihito Tashima and Sumphan Wongseripipatana and Kaori Misawa and Mariko Kitajima and Hiromitsu Takayama and Syunji Horie},
  journal={European journal of pharmacology},
  year={2006},
  volume={549 1-3},
  pages={63-70}
}
7-hydroxymitragynine, a constituent of the Thai herbal medicine Mitragyna speciosa, has been found to have a potent opioid antinociceptive effect. In the present study, we investigated the mechanism of antinociception and the inhibitory effect on gastrointestinal transit of 7-hydroxymitragynine, and compared its effects with those of morphine. When administered subcutaneously to mice, 7-hydroxymitragynine produced antinociceptive effects about 5.7 and 4.4 times more potent than those of… CONTINUE READING

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