Involvement of mouse Rev3 in tolerance of endogenous and exogenous DNA damage.

@article{Sloun2002InvolvementOM,
  title={Involvement of mouse Rev3 in tolerance of endogenous and exogenous DNA damage.},
  author={Petra P H Van Sloun and Isabelle Varlet and Edwin Sonneveld and Jan J. W. A. Boei and Ron J. Romeijn and Jan C. J. Eeken and Niels de Wind},
  journal={Molecular and cellular biology},
  year={2002},
  volume={22 7},
  pages={2159-69}
}
The Rev3 gene of Saccharomyces cerevisiae encodes the catalytic subunit of DNA polymerase zeta that is implicated in mutagenic translesion synthesis of damaged DNA. To investigate the function of its mouse homologue, we have generated mouse embryonic stem cells and mice carrying a targeted disruption of Rev3. Although some strain-dependent variation was observed, Rev3(-/-) embryos died around midgestation, displaying retarded growth in the absence of consistent developmental abnormalities. Rev3… CONTINUE READING