Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over

  title={Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over},
  author={Sean M. Baker and Annemieke W. Plug and Tomas A. Prolla and Christian Eric Bronner and Allie C. Harris and Xiang Yao and D Christie and Craig Monell and Norm Arnheim and Allan Bradley and T Clay Ashley and R. Michael Liskay},
  journal={Nature Genetics},
Mice that are deficient in either the Pms2 or Msh2 DNA mismatch repair genes have microsatellite instability and a predisposition to tumours. Interestingly, Pms2–deficient males display sterility associated with abnormal chromosome pairing in meiosis. Here mice deficient in another mismatch repair gene, Mlh1, possess not only microsatellite instability but are also infertile (both males and females). Mlh 1 –deficient spermatocytes exhibit high levels of prematurely separated chromosomes and… CONTINUE READING
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