Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over

@article{Baker1996InvolvementOM,
  title={Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over},
  author={S. M. Baker and A. Plug and T. Prolla and C. E. Bronner and A. C. Harris and X. Yao and Donna-Marie Christie and C. Monell and N. Arnheim and A. Bradley and T. Ashley and R. Liskay},
  journal={Nature Genetics},
  year={1996},
  volume={13},
  pages={336-342}
}
  • S. M. Baker, A. Plug, +9 authors R. Liskay
  • Published 1996
  • Biology, Medicine
  • Nature Genetics
  • Mice that are deficient in either the Pms2 or Msh2 DNA mismatch repair genes have microsatellite instability and a predisposition to tumours. Interestingly, Pms2–deficient males display sterility associated with abnormal chromosome pairing in meiosis. Here mice deficient in another mismatch repair gene, Mlh1, possess not only microsatellite instability but are also infertile (both males and females). Mlh 1 –deficient spermatocytes exhibit high levels of prematurely separated chromosomes and… CONTINUE READING
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