Involvement of mitogen-activated protein kinase in the cytokine-regulated phosphorylation of transcription factor GATA-1.

Abstract

Gene-targeting experiments in transgenic mice have revealed an essential role for GATA-1 in the normal differentiation and development of erythroid cells. GATA-1 is phosphorylated in vivo on seven of its serine residues; the regulation and function of GATA-1 phosphorylation, however, is not understood. Here we demonstrate a role for MAP kinase (MAPK… (More)

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@article{Towatari2004InvolvementOM, title={Involvement of mitogen-activated protein kinase in the cytokine-regulated phosphorylation of transcription factor GATA-1.}, author={Masayuki Towatari and Marco Cir{\'o} and Sergio Ottolenghi and Shinobu Tsuzuki and Tariq Enver}, journal={The hematology journal : the official journal of the European Haematology Association}, year={2004}, volume={5 3}, pages={262-72} }