Involvement of mitogen-activated protein kinase and NF-kappaB activation in Ca2+-induced IL-8 production in human mast cells.

@article{Kim2005InvolvementOM,
  title={Involvement of mitogen-activated protein kinase and NF-kappaB activation in Ca2+-induced IL-8 production in human mast cells.},
  author={Mi Sun Kim and Woon Ki Lim and Rae Kil Park and Taekyun Shin and Young Joon Yoo and S -S. Hong and Ning An and Hyung Min Kim},
  journal={Cytokine},
  year={2005},
  volume={32 5},
  pages={
          226-33
        }
}
Interleukin-8 (IL-8) is a potent proinflammatory chemokine that plays an important role in inflammation by activating and recruiting neutrophils, lymphocytes, and eosinophils. To demonstrate the effect of intracellular Ca(2+) on IL-8 production and related signaling, we stimulated human mast cell line HMC-1 with either calcium ionophore A23187 or thapsigargin. Increase of intracellular Ca(2+) resulted in inducing IL-8 gene expression and protein secretion, and addition of EGTA or BAPTA/AM… CONTINUE READING
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