Involvement of mitochondrial permeability transition in acetaminophen-induced liver injury in mice.

@article{Masubuchi2005InvolvementOM,
  title={Involvement of mitochondrial permeability transition in acetaminophen-induced liver injury in mice.},
  author={Yasuhiro Masubuchi and Chieko Suda and Toshiharu Horie},
  journal={Journal of hepatology},
  year={2005},
  volume={42 1},
  pages={110-6}
}
BACKGROUND/AIMS Although mitochondria have been demonstrated as primary targets in acetaminophen hepatotoxicity, the mechanism for mitochondria-mediated toxicity has not been defined. We examined the role of mitochondrial permeability transition (MPT) in the acetaminophen-induced liver injury. METHODS Male CD-1 mice were given intraperitoneally acetaminophen (350 mg/kg) without or with cyclosporin A (50 mg/kg), a specific inhibitor of MPT. Serum alanine aminotransferase (ALT), a marker of… CONTINUE READING
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