Involvement of microtubules in the link between cell volume and pH of acidic cellular compartments in rat and human hepatocytes.

@article{Busch1994InvolvementOM,
  title={Involvement of microtubules in the link between cell volume and pH of acidic cellular compartments in rat and human hepatocytes.},
  author={Gillian L. Busch and Rainer Schreiber and Peter C. Dartsch and Harald Voelkl and Stephan vom Dahl and Dieter H{\"a}ussinger and Florian Lang},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1994},
  volume={91 19},
  pages={
          9165-9
        }
}
Cell swelling is shown to induce an increase in acridine orange fluorescence intensity, an effect pointing to the alkalinization of acidic vesicles. Since autophagic hepatic proteolysis is accomplished by pH-sensitive proteinases within acidic lysosomes, this effect may contribute to the well-known inhibitory effect of cell swelling on proteolysis. In the present study, the role of microtubules in volume-dependent alterations of pH in acidic vesicles of rat and human hepatocytes was studied… CONTINUE READING

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