Involvement of membrane signaling in the bystander effect in irradiated cells.

@article{Nagasawa2002InvolvementOM,
  title={Involvement of membrane signaling in the bystander effect in irradiated cells.},
  author={Hatsumi Nagasawa and Aida E. Cremesti and Richard N. Kolesnick and Zvi Fuks and J. B. Little},
  journal={Cancer research},
  year={2002},
  volume={62 9},
  pages={2531-4}
}
We have shown previously that when confluent cultures of mammalian cells are exposed to very low fluences of alpha particles, fluences whereby only 1-3% of the cell nuclei are traversed by a particle, genetic effects, including specific gene mutations and sister chromatid exchanges, are induced in neighboring, nonirradiated ("bystander") cells (H. Nagasawa and J. B. Little, Cancer Res., 52: 6394-6396, 1992; H. Nagasawa and J. B. Little, Radiat. Res., 152: 552-557, 1999). The present experiments… CONTINUE READING
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Direct evidence for the participation of gap junction-mediated intercellular communication in the transmission of damage signals from -particle irradiated to nonirradiated cells

  • E. I. Azzam, S. M. de Toledo, J. B. Little
  • Proc. Natl. Acad. Sci. USA,
  • 2001
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