Involvement of let-7/miR-98 microRNAs in the regulation of progesterone receptor membrane component 1 expression in ovarian cancer cells.

@article{Wendler2011InvolvementOL,
  title={Involvement of let-7/miR-98 microRNAs in the regulation of progesterone receptor membrane component 1 expression in ovarian cancer cells.},
  author={Alexandra Wendler and Daniela Barbara Keller and Christian Albrecht and John J. Peluso and Martin Wehling},
  journal={Oncology reports},
  year={2011},
  volume={25 1},
  pages={273-9}
}
PGRMC1 (progesterone receptor membrane component 1) is part of a multi-protein complex, that is highly expressed in several cancers and is involved in chemoresistance. Although PGRMC1 plays an important role in various cancers, little is known about how PGRMC1 expression is regulated. Therefore, the present study was designed to elucidate the molecular mechanisms that influence PGRMC1 expression in ovarian cancer cells. An in silico approach revealed that the 3'-untranslated region of PGRMC1… CONTINUE READING
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