Involvement of large-conductance Ca(2+) -activated K(+) channels in both nitric oxide and endothelium-derived hyperpolarization-type relaxation in human penile small arteries.

@article{Kiraly2013InvolvementOL,
  title={Involvement of large-conductance Ca(2+) -activated K(+) channels in both nitric oxide and endothelium-derived hyperpolarization-type relaxation in human penile small arteries.},
  author={Istvan Kiraly and J{\'a}nos Pataricza and Zolt{\'a}n Bajory and Ulf Simonsen and Andr{\'a}s Varr{\'o} and Julius Gy Papp and L{\'a}szl{\'o} Pajor and Attila Kun},
  journal={Basic & clinical pharmacology & toxicology},
  year={2013},
  volume={113 1},
  pages={19-24}
}
Large-conductance Ca(2+) -activated K(+) channels (BKC a ), located on the vascular smooth muscle, play an important role in regulation of vascular tone. In penile corpus cavernosum tissue, opening of BKC a channels leads to relaxation of corporal smooth muscle, which is essential during erection; however, there is little information on the role of BKC a channels located in penile vascular smooth muscle. This study was designed to investigate the involvement of BKC a channels in endothelium… CONTINUE READING
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