Involvement of iron (ferric) reduction in the iron absorption mechanism of a trivalent iron-protein complex (iron protein succinylate).

@article{Raja2000InvolvementOI,
  title={Involvement of iron (ferric) reduction in the iron absorption mechanism of a trivalent iron-protein complex (iron protein succinylate).},
  author={Kishor B. Raja and Shahnaz E. Jafri and David Dickson and Alvaro Acebron and Piero Cremonesi and Giacomo Fossati and Robert J. Simpson},
  journal={Pharmacology & toxicology},
  year={2000},
  volume={87 3},
  pages={108-15}
}
Iron protein succinylate is a non-toxic therapeutic iron compound. We set out to characterise the structure of this compound and investigate the importance of digestion and intestinal reduction in determining absorption of the compound. The structure of the compound was investigated by variable temperature Mössbauer spectroscopy, molecular size determinations and kinetics of iron release by chelators. Intestinal uptake was determined with radioactive compound force fed to mice. Reduction of the… CONTINUE READING