Involvement of intracellular glutathione in zinc deficiency-induced activation of hepatic stellate cells.

@article{KojimaYuasa2003InvolvementOI,
  title={Involvement of intracellular glutathione in zinc deficiency-induced activation of hepatic stellate cells.},
  author={Akiko Kojima-Yuasa and Tomoko Ohkita and Kumiko Yukami and Hiroko Ichikawa and Noriko Takami and Teruyo Nakatani and David Opare Kennedy and Shuhei Nishiguchi and Isao Matsui-Yuasa},
  journal={Chemico-biological interactions},
  year={2003},
  volume={146 1},
  pages={
          89-99
        }
}
Hepatic stellate cells (HSC) play an important role in the development of liver cirrhosis. They are a major source of extracellular matrix and during fibrogenesis undergo an activation process characterized by increased proliferation and collagen synthesis. In this study, we investigated the anti-fibrogenic effect of zinc supplementation on zinc deficiency induced HSC activation. Isolated HSC were incubated with or without zinc chelator, diethylenetriamine penta-acetic acid (DTPA). Type I… CONTINUE READING
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