Involvement of interleukin-21 in the regulation of colitis-associated colon cancer

@inproceedings{Stolfi2011InvolvementOI,
  title={Involvement of interleukin-21 in the regulation of colitis-associated colon cancer},
  author={Carmine Stolfi and Angelamaria Rizzo and Eleonora Franz{\`e} and Angela Rotondi and Massimo Claudio Fantini and Massimiliano Sarra and Roberta Caruso and Ivan Monteleone and Pierpaolo Sileri and Luana Franceschilli and Flavio Andrea Caprioli and Stefano Ferrero and Thomas Macdonald and Francesco Pallone and Giovanni Monteleone},
  booktitle={The Journal of experimental medicine},
  year={2011}
}
Chronic inflammation is a major driving force in the development of cancer in many tissues, but the array of factors involved in this neoplastic transformation are not well understood. We have investigated the role of interleukin (IL)-21 in colitis-associated colon cancer (CAC), as this cytokine is overexpressed in the gut mucosa of patients with ulcerative colitis (UC), a chronic inflammatory disease associated with colon cancer. IL-21 was increased in the gut of patients with UC-associated… CONTINUE READING