Involvement of interleukin-18 in severe Plasmodium falciparum malaria.

  title={Involvement of interleukin-18 in severe Plasmodium falciparum malaria.},
  author={Yukiko Nagamine and Masashi Hayano and Shin-ichiro Kashiwamura and Haruki Okamura and Kenji Nakanishi and Srivicha Krudsod and Polrat Wilairatana and Sornchai Looareesuwan and Somei Kojima},
  journal={Transactions of the Royal Society of Tropical Medicine and Hygiene},
  volume={97 2},
Serum levels of interleukin-18 (IL-18), interferon-gamma (IFN-gamma), and immunoglobulin E (IgE) were determined for 96 patients with Plasmodium falciparum malaria admitted to hospital, Bangkok, Thailand in the period 1998-2000. The patients were divided into 3 groups, i.e. uncomplicated, severe and cerebral malaria according to WHO criteria (2000). Elevation of IL-18 levels was observed in all 3 groups, with a tendency for higher levels in cases with severe malaria throughout the course of the… CONTINUE READING


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