Involvement of interferon-gamma and macrophage colony-stimulating factor in pathogenesis of haemophagocytic lymphohistiocytosis in adults.

@article{Akashi1994InvolvementOI,
  title={Involvement of interferon-gamma and macrophage colony-stimulating factor in pathogenesis of haemophagocytic lymphohistiocytosis in adults.},
  author={Koichi Akashi and Shin Hayashi and Hisashi Gondo and Shin-ichi Mizuno and M. D. N. Harada and Kazuo Tamura and K Yamasaki and T Tsunefumi Shibuya and Naokuni Uike and Takashi Okamura},
  journal={British journal of haematology},
  year={1994},
  volume={87 2},
  pages={243-50}
}
We investigated the role of monocyte/macrophage-activating cytokines in pathogenesis of haemophagocytic lymphohistiocytosis (HLH) in 21 adult patients. Sera from patients with active HLH contained extremely high levels of macrophage colony-stimulating factor (M-CSF) and of interferon-gamma (IFN-gamma). These levels returned to almost normal during remission. Neither interleukin-4 nor granulocyte/macrophage colony-stimulating factor could be detected. Active HLH sera also contained high… CONTINUE READING
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