Involvement of inflammatory chemokines in survival of human monocytes fed with malarial pigment.

Abstract

Hemozoin (HZ)-fed monocytes are exposed to strong oxidative stress, releasing large amounts of peroxidation derivatives with subsequent impairment of numerous functions and overproduction of proinflammatory cytokines. However, the histopathology at autopsy of tissues from patients with severe malaria showed abundant HZ in Kupffer cells and other tissue… (More)
DOI: 10.1128/IAI.00455-10

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