Involvement of inducible nitric oxide synthase in inflammation-induced dopaminergic neurodegeneration

@article{Iravani2002InvolvementOI,
  title={Involvement of inducible nitric oxide synthase in inflammation-induced dopaminergic neurodegeneration},
  author={Mahmoud M Iravani and Kirk Kashefi and Poonam Mander and Sarah Rose and Patricia Jenner},
  journal={Neuroscience},
  year={2002},
  volume={110},
  pages={49-58}
}
The loss of dopaminergic neurones in the substantia nigra with Parkinson's disease may result from inflammation-induced proliferation of microglia and reactive macrophages expressing inducible nitric oxide synthase (iNOS). We have investigated the effects of the supranigral administration of lipopolysaccharide on iNOS-immunoreactivity, 3-nitrotyrosine formation and tyrosine hydroxylase-immunoreactive neuronal number, and retrogradely labelled fluorogold-positive neurones in the ventral… CONTINUE READING
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