Involvement of inducible costimulator-B7 homologous protein costimulatory pathway in murine lupus nephritis.

  title={Involvement of inducible costimulator-B7 homologous protein costimulatory pathway in murine lupus nephritis.},
  author={Hideyuki Iwai and Masaaki Abe and S. Hirose and Fumihiko Tsushima and Katsunari Tezuka and Hisaya Akiba and H. Yagita and Ko Okumura and Hitoshi Kohsaka and Nobuyuki Miyasaka and Miyuki Azuma},
  journal={Journal of immunology},
  volume={171 6},
Inducible costimulator (ICOS)-B7 homologous protein (B7h) is a new member of the CD28-B7 family of costimulatory molecules that regulates T cell-dependent humoral immune responses. In this study, we examined the involvement of this costimulatory pathway in the development and progression of lupus in NZB/W F(1) mice. Expression of ICOS on T cells was enhanced with disease progression, whereas B7h expression on B cells was down-regulated. Administration of anti-B7h mAb before the onset of renal… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 57 extracted citations

Targeting of the immune system in systemic lupus erythematosus.

Expert reviews in molecular medicine • 2008
View 4 Excerpts
Highly Influenced

Experimental anti-GBM nephritis as an analytical tool for studying spontaneous lupus nephritis

Archivum Immunologiae et Therapiae Experimentalis • 2008
View 13 Excerpts
Highly Influenced

Follicular helper T cell in immunity and autoimmunity.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas • 2016


Publications referenced by this paper.
Showing 1-10 of 49 references

Murine models of systemic lupus erythematosus.

Advances in immunology • 1985
View 7 Excerpts
Highly Influenced

ICOS-ligand, expressed on human endothelial cells, costimulates Th1 and Th2 cytokine secretion by memory CD4+ T cells.

Proceedings of the National Academy of Sciences of the United States of America • 2002
View 1 Excerpt

Similar Papers

Loading similar papers…