Involvement of inducible costimulator-B7 homologous protein costimulatory pathway in murine lupus nephritis.

@article{Iwai2003InvolvementOI,
  title={Involvement of inducible costimulator-B7 homologous protein costimulatory pathway in murine lupus nephritis.},
  author={Hideyuki Iwai and Masaaki Abe and S. Hirose and Fumihiko Tsushima and Katsunari Tezuka and Hisaya Akiba and H. Yagita and Ko Okumura and Hitoshi Kohsaka and Nobuyuki Miyasaka and Miyuki Azuma},
  journal={Journal of immunology},
  year={2003},
  volume={171 6},
  pages={2848-54}
}
Inducible costimulator (ICOS)-B7 homologous protein (B7h) is a new member of the CD28-B7 family of costimulatory molecules that regulates T cell-dependent humoral immune responses. In this study, we examined the involvement of this costimulatory pathway in the development and progression of lupus in NZB/W F(1) mice. Expression of ICOS on T cells was enhanced with disease progression, whereas B7h expression on B cells was down-regulated. Administration of anti-B7h mAb before the onset of renal… CONTINUE READING

Citations

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References

Publications referenced by this paper.
Showing 1-10 of 49 references

Murine models of systemic lupus erythematosus.

Advances in immunology • 1985
View 7 Excerpts
Highly Influenced

ICOS-ligand, expressed on human endothelial cells, costimulates Th1 and Th2 cytokine secretion by memory CD4+ T cells.

Proceedings of the National Academy of Sciences of the United States of America • 2002
View 1 Excerpt

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