Involvement of iNOS-dependent NO production in the stimulation of osteoclast survival by TNF-alpha.

@article{Lee2004InvolvementOI,
  title={Involvement of iNOS-dependent NO production in the stimulation of osteoclast survival by TNF-alpha.},
  author={Seung Ku Lee and Hao Huang and Soo Woong Lee and Kyung Hee Kim and Kyung Keun Kim and Hyun-Man Kim and Zang Hee Lee and Hong-Hee Kim},
  journal={Experimental cell research},
  year={2004},
  volume={298 2},
  pages={
          359-68
        }
}
Osteoclasts, cells primarily responsible for bone resorption, differentiate from hematopoietic progenitor cells under the influence of various hormones, cytokines, and differentiation factors. Once fully differentiated, osteoclasts rapidly die in the absence of any survival factor. We have previously shown that tumor necrosis factor alpha (TNF-alpha) promotes the survival of differentiated osteoclasts. The expression of inducible nitric oxide synthase (iNOS) and consequent NO production is… CONTINUE READING
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